POD: Gender swap of Louis of France and Anne of Brittany's children.
King Louis XII (1462-1515) m. Anne, Duchess of Brittany (1477-1514)
1. King Claude I "the Ugly" "the Hunchback" "the Good" "the Knight-King" "the Golden" (1499-1564) m. Eleanor of Austria (1498-1558).
1. Dauphin Louis (1518-1521).
2. Dauphin Francois of France (1519-1559) m. Catherine of England (1518-1558).
3. Princess Marie (1520-1524).
4. Princess Charles, Duke of Berry (1522-1544) m. Anne of Lorraine (1522-1568)
5. Princess Anne (1523-1574) m. King James IV (1512-1542).
6. Prince Louis, Duke of Anjou (1525-1557).
7. Princess Claude Eleanor (1531-1577).
2. Francois, Duke of Orleans and Brittany "The Heretic" (1510-1574) m. Isabella of Navarre (1512-1560).
1. Anne (1531-1607).
2. Claude, Duke of Orleans and Brittany (1533-1597).
3. Francois (1535-1598).
4. Isabel (1537-1581).
5. Louis (1538-1586).
Claude's enemies love to deride him for his appearance but once he ascended the throne, he proved himself to be a capable and good ruler. The only blight on his reign was him turning a blind eye to his brother's rising Calvinist leanings which caused the TL wars of religion after his death. His grandson, Claude, was less tolerant. His daughter in law is either the OTL stillborn daughter of Katherine and Henry or the youngest daughter of KOA and Arthur, you decided.