Manuel I of Portugal,
Duke of Beja and Viseu (1469-1521) m. Isabel of Castile and Aragon,
Princess of Asturias and Girona (1470-1498)
1. Miguel I,
de la Paz, of Portugal, Spain and Sicily (1498-1552) m. Eleanor of Austria (1498-1562)
a. Isabel of Portugal and Spain (1516-1572) m. Edward VI, King of England (1513-1569)
b. Juana of Spain and Portugal (1517-1542) m. Francis III, Duke of Brittany
c. Ferdinand, Prince of Portugal Asturias and Girona (1519-1531)
d. Juan III, King of Portugal and Spain, (1519-1567) m. Isabel d'Albret of Navarre (1512-1560)
e. Maria of Portugal and Spain (1522-1523)
f. Leanor of Portugal and Spain (1525-1578) m. Philip I, HRE, archduke of Austria
g. Manuel II, Duke of Beja and Granada (1526-1581) m. ??
h. Miguel II, Duke of Viseu and Barcelona (1530 -1570) m. ??
### Context: Miguel de la Paz survives but Isabel of Aragon dies in childbirth. Since Miguel is healthy and prosperous, Manuel leaves him in the care of his maternal grandparents and visits him from time to time. Back in Portugal, however, Manuel refuses to marry a second time even after the Catholic Monarchs offer their daughter, Maria of Aragon. Manuel, when not attending royal duties or tending to his son, dedicates his time to writing poetry in the honour of his decessed wife, a feat that would earn him the nickname "the Loyal" or "the Poet-King". As days passed, Manuel went deeper into the idea that Isabel was always near him in the spirit state, going as far as to construct life size marble statues of Isabel that were kept in his bedroom, study and even the royal court occupying the throne when court proceedings took place. Accordingly, Manuel would also read out his poems to these statues, decorate them with jewels and give them flowers.